Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
Ageing is associated with muscle atrophy. Here, the authors show that the secreted glycoprotein Dickkopf 3 promotes muscle atrophy by inducing nuclear import of beta-catenin, its association with FoxO3 and the consequent activation of the atrophy-related genes Atrogin1 and MuRF1.
Bibliographic Details
| Main Authors: |
Jie Yin,
Lele Yang,
Yangli Xie,
Yan Liu,
Sheng Li,
Wenjun Yang,
Bo Xu,
Hongbin Ji,
Lianghua Ding,
Kun Wang,
Gang Li,
Lin Chen,
Ping Hu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-04038-6
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