The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison

The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison

Drug dosing adjustment in sepsis-induced acute kidney injury (sepsis-AKI) is currently adjusted based on renal function. Sepsis is a multiorgan injury, and thus, drug metabolism in sepsis-AKI might be interfered by non-renal factors such as changes in functions of drug-metabolizing enzymes in the li...

Full description

Bibliographic Details
Main Authors: Warumphon Sukkummee, Patcharin Jittisak, Piyanuch Wonganan, Supeecha Wittayalertpanya, Pajaree Chariyavilaskul, Asada Leelahavanichkul
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Renal Failure
Subjects:
cytochrome p450
mouse model
renal impairment
sepsis
Online Access:http://dx.doi.org/10.1080/0886022X.2019.1602054

Internet

http://dx.doi.org/10.1080/0886022X.2019.1602054

Similar Items