Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes

Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes

<p>Abstract</p> <p>Background</p> <p>Obesity is a state of subclinical inflammation resulting in loss of function of insulin receptors and decreased insulin sensitivity. Inhibition of the inflammatory enzymes, matrix metalloproteinases (MMPs), for 6 months in rodent mod...

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Bibliographic Details
Main Authors: Frankwich Karen, Tibble Courtney, Torres-Gonzalez Moises, Bonner Mariah, Lefkowitz Roy, Tyndall Matt, Schmid-Schönbein Geert W, Villarreal Francisco, Heller Mike, Herbst Karen
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Journal of Inflammation
Subjects:
Diabetes
Doxycycline
Insulin sensitivity
Matrix metalloproteinases
Myeloperoxidase
Online Access:http://www.journal-inflammation.com/content/9/1/35

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