Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism

Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism

Fibroblast growth factor-21 (FGF21) levels are elevated in patients with primary mitochondrial disorders but have not been studied in patients with inborn errors of metabolism (IEM) known to have secondary mitochondrial dysfunction. We measured plasma FGF21 by ELISA in patients with and without IEM....

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Main Authors: Brian Kirmse, Juan Cabrerra-Luque, Omar Ayyub, Kristina Cusmano, Kimberly Chapman, Marshall Summar
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Genetics and Metabolism Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426917300253
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spelling doaj-9d209d9c70ae4a5189cf1377e3b362732020-11-24T22:39:23ZengElsevierMolecular Genetics and Metabolism Reports2214-42692017-12-0113C525410.1016/j.ymgmr.2017.04.001Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolismBrian Kirmse0Juan Cabrerra-Luque1Omar Ayyub2Kristina Cusmano3Kimberly Chapman4Marshall Summar5University of Mississippi Medical Center, Department of Pediatrics, Jackson, MS, United StatesChildren's National Health System, Division of Genetics & Metabolism, Washington, DC, United StatesChildren's National Health System, Division of Genetics & Metabolism, Washington, DC, United StatesChildren's National Health System, Division of Genetics & Metabolism, Washington, DC, United StatesChildren's National Health System, Division of Genetics & Metabolism, Washington, DC, United StatesChildren's National Health System, Division of Genetics & Metabolism, Washington, DC, United StatesFibroblast growth factor-21 (FGF21) levels are elevated in patients with primary mitochondrial disorders but have not been studied in patients with inborn errors of metabolism (IEM) known to have secondary mitochondrial dysfunction. We measured plasma FGF21 by ELISA in patients with and without IEM. FGF21 levels were higher in patients with IEM compared to without IEM (370 pg/dL vs. 0–65 pg/dL). Further study of FGF21 as a biomarker in IEM is warranted.http://www.sciencedirect.com/science/article/pii/S2214426917300253
collection DOAJ
language English
format Article
sources DOAJ
author Brian Kirmse
Juan Cabrerra-Luque
Omar Ayyub
Kristina Cusmano
Kimberly Chapman
Marshall Summar
spellingShingle Brian Kirmse
Juan Cabrerra-Luque
Omar Ayyub
Kristina Cusmano
Kimberly Chapman
Marshall Summar
Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism
Molecular Genetics and Metabolism Reports
author_facet Brian Kirmse
Juan Cabrerra-Luque
Omar Ayyub
Kristina Cusmano
Kimberly Chapman
Marshall Summar
author_sort Brian Kirmse
title Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism
title_short Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism
title_full Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism
title_fullStr Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism
title_full_unstemmed Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism
title_sort plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism
publisher Elsevier
series Molecular Genetics and Metabolism Reports
issn 2214-4269
publishDate 2017-12-01
description Fibroblast growth factor-21 (FGF21) levels are elevated in patients with primary mitochondrial disorders but have not been studied in patients with inborn errors of metabolism (IEM) known to have secondary mitochondrial dysfunction. We measured plasma FGF21 by ELISA in patients with and without IEM. FGF21 levels were higher in patients with IEM compared to without IEM (370 pg/dL vs. 0–65 pg/dL). Further study of FGF21 as a biomarker in IEM is warranted.
url http://www.sciencedirect.com/science/article/pii/S2214426917300253
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AT kristinacusmano plasmafibroblastgrowthfactor21levelsinpatientswithinbornerrorsofmetabolism
AT kimberlychapman plasmafibroblastgrowthfactor21levelsinpatientswithinbornerrorsofmetabolism
AT marshallsummar plasmafibroblastgrowthfactor21levelsinpatientswithinbornerrorsofmetabolism
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