Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption.

Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption.

Numerous neurological disorders are characterized by central nervous system (CNS) vascular permeability. However, the underlying contribution of inflammatory-derived factors leading to pathology associated with blood-brain barrier (BBB) disruption remains poorly understood. In order to address this,...

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Bibliographic Details
Main Authors: Holly L Johnson, Robin C Willenbring, Fang Jin, Whitney A Manhart, Stephanie J LaFrance, Istvan Pirko, Aaron J Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4206459?pdf=render

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