EFFECTS OF SOME MICHAEL TYPE ADDITION PRODUCTS ON VARIOUS CYTOKINES
The aim of this research in to investigate the anticytokine activities of the 2-[(2-nitro-l-phenylpropyl)thio]benzoic acid (1), 2-[(2-nitro-l-phenylethyl)thiomethyl]benzimidazole (2) and 2-[(2-nitro-l-phenylpropyl)thiomethyl]benzimidazole (3) derivatives in human primary cells and cell lines. Cytoki...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2011-04-01
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| Series: | Türk Yoğun Bakim Derneği Dergisi |
| Subjects: | |
| Online Access: | http://www.turkjps.org/archives/archive-detail/article-preview/effects-of-some-mchael-type-addton-products-on-var/12468 |
| Summary: | The aim of this research in to investigate the anticytokine activities of the 2-[(2-nitro-l-phenylpropyl)thio]benzoic acid (1), 2-[(2-nitro-l-phenylethyl)thiomethyl]benzimidazole (2) and 2-[(2-nitro-l-phenylpropyl)thiomethyl]benzimidazole (3) derivatives in human primary cells and cell lines. Cytokines are messengers for the regulation of the inflammatory cascades with Tumor Necrosis Factor-a (TNF-a), Interleukin (IL-lβ, IL-2, IL-4 andIL-8), Gamma Interferon (IFN-y) working synergistically. In this study which is performed in cell assay, inhibition capacity of compound 1, 2 and 3 derivatives againts TNF-a, IL-Iβ, IL-8, IL-2, IL-4 and IFN-y production by human whole blood have been measured. The test results were shown that 1, 2 and 3 derivatives have dose-dependent inhibitions on the release of IL-1β, IL-8 and TNF-a in lipopolysaccharide (LPS) stimulated human whole blood and IL-2, IL-4 and IFN-yin phorbolacetate (PHA) stimulated in human whole blood |
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| ISSN: | 1304-530X 2146-6416 |