Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence

Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence

Background and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and drug addiction. With regard to this, in this...

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Main Authors: Krasteva M., Koycheva Y., Taseva T., Simeonova S.
Format: Article
Language:English
Published: Sciendo 2020-11-01
Series:Acta Medica Bulgarica
Subjects:
dna methylation
gene expression
mrna
alcohol dependence
drug dependence
Online Access:https://doi.org/10.2478/amb-2020-0039
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spelling doaj-9d169e4b4bd34e30be71c3c2e00233552021-07-01T05:22:03ZengSciendoActa Medica Bulgarica0324-17502020-11-01474111710.2478/amb-2020-0039Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug DependenceKrasteva M.0Koycheva Y.1Taseva T.2Simeonova S.3Institute of Plant Physiology and Genetics, Laboratory of Genome Dynamics and Stability, Bulgarian Academy of Sciences – SofiaBulgariaInstitute of Plant Physiology and Genetics, Laboratory of Genome Dynamics and Stability, Bulgarian Academy of Sciences – SofiaBulgariaInstitute of Plant Physiology and Genetics, Laboratory of Genome Dynamics and Stability, Bulgarian Academy of Sciences – SofiaBulgariaInstitute of Plant Physiology and Genetics, Laboratory of Genome Dynamics and Stability, Bulgarian Academy of Sciences – SofiaBulgariaBackground and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and drug addiction. With regard to this, in this study we analyzed the expression levels of genes involved in DNA methylation, including DNMT1, DNMT3a, MeCP2, MBD1, MBD2, MBD3 and MBD4, in blood samples of alcohol and drug dependent persons in comparison to healthy abstainers.https://doi.org/10.2478/amb-2020-0039dna methylationgene expressionmrnaalcohol dependencedrug dependence
collection DOAJ
language English
format Article
sources DOAJ
author Krasteva M.
Koycheva Y.
Taseva T.
Simeonova S.
spellingShingle Krasteva M.
Koycheva Y.
Taseva T.
Simeonova S.
Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
Acta Medica Bulgarica
dna methylation
gene expression
mrna
alcohol dependence
drug dependence
author_facet Krasteva M.
Koycheva Y.
Taseva T.
Simeonova S.
author_sort Krasteva M.
title Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_short Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_full Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_fullStr Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_full_unstemmed Changes in the Expression of DNA Methylation Related Genes in Leukocytes of Persons with Alcohol and Drug Dependence
title_sort changes in the expression of dna methylation related genes in leukocytes of persons with alcohol and drug dependence
publisher Sciendo
series Acta Medica Bulgarica
issn 0324-1750
publishDate 2020-11-01
description Background and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and drug addiction. With regard to this, in this study we analyzed the expression levels of genes involved in DNA methylation, including DNMT1, DNMT3a, MeCP2, MBD1, MBD2, MBD3 and MBD4, in blood samples of alcohol and drug dependent persons in comparison to healthy abstainers.
topic dna methylation
gene expression
mrna
alcohol dependence
drug dependence
url https://doi.org/10.2478/amb-2020-0039
work_keys_str_mv AT krastevam changesintheexpressionofdnamethylationrelatedgenesinleukocytesofpersonswithalcoholanddrugdependence
AT koychevay changesintheexpressionofdnamethylationrelatedgenesinleukocytesofpersonswithalcoholanddrugdependence
AT tasevat changesintheexpressionofdnamethylationrelatedgenesinleukocytesofpersonswithalcoholanddrugdependence
AT simeonovas changesintheexpressionofdnamethylationrelatedgenesinleukocytesofpersonswithalcoholanddrugdependence
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