Effects of Lead and Cadmium on Brain Endothelial Cell Survival, Monolayer Permeability, and Crucial Oxidative Stress Markers in an in Vitro Model of the Blood-Brain Barrier

Effects of Lead and Cadmium on Brain Endothelial Cell Survival, Monolayer Permeability, and Crucial Oxidative Stress Markers in an in Vitro Model of the Blood-Brain Barrier

Oxidative stress, which is the loss of balance between antioxidant defense and oxidant production in the cells, is implicated in the molecular mechanism of heavy metal-induced neurotoxicity. Given the key role of lead (Pb) and cadmium (Cd) in inducing oxidative stress, we investigated their role in...

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Bibliographic Details
Main Authors: Shakila Tobwala, Hsiu-Jen Wang, Joshua Warren Carey, William A. Banks, Nuran Ercal
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Toxics
Subjects:
blood brain barrier
reactive oxygen species
neurotoxicty
lead
cadmium
Online Access:http://www.mdpi.com/2305-6304/2/2/258

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