Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures

Abstract Introduction Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures. Objective In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidoca...

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Main Authors: George Francisco S. Santos, Luan Oliveira Ferreira, Bruna Gerrits Mattos, Eliniete J. Fidelis, Alisson S. deSouza, Paula S. Batista, Cecilia A. F. Manoel, Diego Arthur C. Cabral, Vanessa Jóia de Mello, Dielly Catrina Favacho Lopes, Moisés Hamoy
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Brain and Behavior
Subjects:
Online Access:https://doi.org/10.1002/brb3.1940
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spelling doaj-9d113885c54448a0998aedb852cc5bf52021-02-14T15:29:26ZengWileyBrain and Behavior2162-32792021-02-01112n/an/a10.1002/brb3.1940Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizuresGeorge Francisco S. Santos0Luan Oliveira Ferreira1Bruna Gerrits Mattos2Eliniete J. Fidelis3Alisson S. deSouza4Paula S. Batista5Cecilia A. F. Manoel6Diego Arthur C. Cabral7Vanessa Jóia de Mello8Dielly Catrina Favacho Lopes9Moisés Hamoy10Laboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of Experimental Neuropathology João de Barros Barreto University Hospital Federal University of Pará Belém BrazilLaboratory of Experimental Neuropathology João de Barros Barreto University Hospital Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of Experimental Neuropathology João de Barros Barreto University Hospital Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilAbstract Introduction Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures. Objective In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs. The study used adult male Wistar rats to describe of the seizure‐related behavior of LA and investigated the treatment with anticonvulsant drugs. Results The use of LA resulted in clear changes in the ECoG pattern, which presented characteristics of Status epilepticus, with increased intensity in all brainwaves. The decomposition of the cerebral waves showed an increase in the beta and gamma waves that may be related to tonic–clonic seizure. Although the treatment with anticonvulsants drugs reduces the power of brainwaves at frequencies between 1 and 40 Hz compared to the LA group, but only diazepam (DZP) was able to decrease the intensity of oscillations. The muscle contraction power also indicated a difference in the effectiveness of the three treatments. Conclusion The sum of the evidence indicates that LA causes status epilepticus and that DZP is the most effective treatment for the control of these seizures, by restoring the systemic values to levels close to those recorded in the control group.https://doi.org/10.1002/brb3.1940electrocorticographyelectromyographyepilepsylidocaineseizure
collection DOAJ
language English
format Article
sources DOAJ
author George Francisco S. Santos
Luan Oliveira Ferreira
Bruna Gerrits Mattos
Eliniete J. Fidelis
Alisson S. deSouza
Paula S. Batista
Cecilia A. F. Manoel
Diego Arthur C. Cabral
Vanessa Jóia de Mello
Dielly Catrina Favacho Lopes
Moisés Hamoy
spellingShingle George Francisco S. Santos
Luan Oliveira Ferreira
Bruna Gerrits Mattos
Eliniete J. Fidelis
Alisson S. deSouza
Paula S. Batista
Cecilia A. F. Manoel
Diego Arthur C. Cabral
Vanessa Jóia de Mello
Dielly Catrina Favacho Lopes
Moisés Hamoy
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
Brain and Behavior
electrocorticography
electromyography
epilepsy
lidocaine
seizure
author_facet George Francisco S. Santos
Luan Oliveira Ferreira
Bruna Gerrits Mattos
Eliniete J. Fidelis
Alisson S. deSouza
Paula S. Batista
Cecilia A. F. Manoel
Diego Arthur C. Cabral
Vanessa Jóia de Mello
Dielly Catrina Favacho Lopes
Moisés Hamoy
author_sort George Francisco S. Santos
title Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
title_short Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
title_full Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
title_fullStr Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
title_full_unstemmed Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
title_sort electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
publisher Wiley
series Brain and Behavior
issn 2162-3279
publishDate 2021-02-01
description Abstract Introduction Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures. Objective In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs. The study used adult male Wistar rats to describe of the seizure‐related behavior of LA and investigated the treatment with anticonvulsant drugs. Results The use of LA resulted in clear changes in the ECoG pattern, which presented characteristics of Status epilepticus, with increased intensity in all brainwaves. The decomposition of the cerebral waves showed an increase in the beta and gamma waves that may be related to tonic–clonic seizure. Although the treatment with anticonvulsants drugs reduces the power of brainwaves at frequencies between 1 and 40 Hz compared to the LA group, but only diazepam (DZP) was able to decrease the intensity of oscillations. The muscle contraction power also indicated a difference in the effectiveness of the three treatments. Conclusion The sum of the evidence indicates that LA causes status epilepticus and that DZP is the most effective treatment for the control of these seizures, by restoring the systemic values to levels close to those recorded in the control group.
topic electrocorticography
electromyography
epilepsy
lidocaine
seizure
url https://doi.org/10.1002/brb3.1940
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