Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures
Abstract Introduction Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures. Objective In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidoca...
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doaj-9d113885c54448a0998aedb852cc5bf52021-02-14T15:29:26ZengWileyBrain and Behavior2162-32792021-02-01112n/an/a10.1002/brb3.1940Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizuresGeorge Francisco S. Santos0Luan Oliveira Ferreira1Bruna Gerrits Mattos2Eliniete J. Fidelis3Alisson S. deSouza4Paula S. Batista5Cecilia A. F. Manoel6Diego Arthur C. Cabral7Vanessa Jóia de Mello8Dielly Catrina Favacho Lopes9Moisés Hamoy10Laboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of Experimental Neuropathology João de Barros Barreto University Hospital Federal University of Pará Belém BrazilLaboratory of Experimental Neuropathology João de Barros Barreto University Hospital Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilLaboratory of Experimental Neuropathology João de Barros Barreto University Hospital Federal University of Pará Belém BrazilLaboratory of the Pharmacology and Toxicology of Natural Products Institute of Biological Sciences Federal University of Pará Belém BrazilAbstract Introduction Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures. Objective In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs. The study used adult male Wistar rats to describe of the seizure‐related behavior of LA and investigated the treatment with anticonvulsant drugs. Results The use of LA resulted in clear changes in the ECoG pattern, which presented characteristics of Status epilepticus, with increased intensity in all brainwaves. The decomposition of the cerebral waves showed an increase in the beta and gamma waves that may be related to tonic–clonic seizure. Although the treatment with anticonvulsants drugs reduces the power of brainwaves at frequencies between 1 and 40 Hz compared to the LA group, but only diazepam (DZP) was able to decrease the intensity of oscillations. The muscle contraction power also indicated a difference in the effectiveness of the three treatments. Conclusion The sum of the evidence indicates that LA causes status epilepticus and that DZP is the most effective treatment for the control of these seizures, by restoring the systemic values to levels close to those recorded in the control group.https://doi.org/10.1002/brb3.1940electrocorticographyelectromyographyepilepsylidocaineseizure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
George Francisco S. Santos Luan Oliveira Ferreira Bruna Gerrits Mattos Eliniete J. Fidelis Alisson S. deSouza Paula S. Batista Cecilia A. F. Manoel Diego Arthur C. Cabral Vanessa Jóia de Mello Dielly Catrina Favacho Lopes Moisés Hamoy |
spellingShingle |
George Francisco S. Santos Luan Oliveira Ferreira Bruna Gerrits Mattos Eliniete J. Fidelis Alisson S. deSouza Paula S. Batista Cecilia A. F. Manoel Diego Arthur C. Cabral Vanessa Jóia de Mello Dielly Catrina Favacho Lopes Moisés Hamoy Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures Brain and Behavior electrocorticography electromyography epilepsy lidocaine seizure |
author_facet |
George Francisco S. Santos Luan Oliveira Ferreira Bruna Gerrits Mattos Eliniete J. Fidelis Alisson S. deSouza Paula S. Batista Cecilia A. F. Manoel Diego Arthur C. Cabral Vanessa Jóia de Mello Dielly Catrina Favacho Lopes Moisés Hamoy |
author_sort |
George Francisco S. Santos |
title |
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures |
title_short |
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures |
title_full |
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures |
title_fullStr |
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures |
title_full_unstemmed |
Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures |
title_sort |
electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures |
publisher |
Wiley |
series |
Brain and Behavior |
issn |
2162-3279 |
publishDate |
2021-02-01 |
description |
Abstract Introduction Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures. Objective In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs. The study used adult male Wistar rats to describe of the seizure‐related behavior of LA and investigated the treatment with anticonvulsant drugs. Results The use of LA resulted in clear changes in the ECoG pattern, which presented characteristics of Status epilepticus, with increased intensity in all brainwaves. The decomposition of the cerebral waves showed an increase in the beta and gamma waves that may be related to tonic–clonic seizure. Although the treatment with anticonvulsants drugs reduces the power of brainwaves at frequencies between 1 and 40 Hz compared to the LA group, but only diazepam (DZP) was able to decrease the intensity of oscillations. The muscle contraction power also indicated a difference in the effectiveness of the three treatments. Conclusion The sum of the evidence indicates that LA causes status epilepticus and that DZP is the most effective treatment for the control of these seizures, by restoring the systemic values to levels close to those recorded in the control group. |
topic |
electrocorticography electromyography epilepsy lidocaine seizure |
url |
https://doi.org/10.1002/brb3.1940 |
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