Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques

Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques

Non-human primates (NHP) are the only animal model suitable to evaluate the protection efficacy of HIV-1 vaccines. It is important to understand how and when neutralizing antibodies (nAbs) with specificities similar to those of human broadly neutralizing antibodies (bnAbs) develop in NHPs. To addres...

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Bibliographic Details
Main Authors: Nan Gao, Yanxin Gai, Lina Meng, Chu Wang, Xin Zhang, Wei Wang, Chuan Qin, Xianghui Yu, Feng Gao
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Viruses
Subjects:
simian/human immunodeficiency virus
neutralizing antibody
specificities
non-human primate
escape mutation
Online Access:https://www.mdpi.com/1999-4915/12/2/163

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