Pharmacogenetics of the safety of phenazepam in alcohol withdrawal syndrome: haplotype and combinatorial analyses of polymorphic variants in the pharmacokinetic factor genes

Pharmacogenetics of the safety of phenazepam in alcohol withdrawal syndrome: haplotype and combinatorial analyses of polymorphic variants in the pharmacokinetic factor genes

Phenazepam is a benzodiazepine tranquilizer that is widely used in Russia. The drug is metabolized by cytochrome P450 3A (CYP3A) isozymes. Since their substrates have an affinity for P-glycoprotein, the polymorphic variants in the ABCB1 gene may affect the safety of this drug.Objective: to analyze a...

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Bibliographic Details
Main Authors: D. V. Ivashchenko, O. V. Tereshchenko, I. I. Temirbulatov, K. A. Akmalova, E. A. Grishina, M. S. Zastrozhin, L. M. Savchenko, E. A. Bryun, D. A. Sychev
Format: Article
Language:Russian
Published: IMA-PRESS LLC 2020-04-01
Series:Nevrologiâ, Nejropsihiatriâ, Psihosomatika
Subjects:
phenazepam
alcohol withdrawal syndrome
pharmacogenetics
haplotypes
cytochromes p450
p-glycoprotein
Online Access:https://nnp.ima-press.net/nnp/article/view/1299

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