Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound

Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound

Autophagic cell death (ACD) is an alternative death mechanism in resistant malignant cancer cells. In this study, we demonstrated how polyphenol stilbene compound PE5 exhibits potent ACD-promoting activity in lung cancer cells that may offer an opportunity for novel cancer treatment. Cell death caus...

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Bibliographic Details
Main Authors: Sucharat Tungsukruthai, Onrapak Reamtong, Sittiruk Roytrakul, Suchada Sukrong, Chanida Vinayanwattikun, Pithi Chanvorachote
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
autophagy
polyphenol
stilbene compounds
proteomics
lung cancer
autophagic cell death
Online Access:https://www.mdpi.com/2076-3921/10/4/534

Internet

https://www.mdpi.com/2076-3921/10/4/534

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