P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells

P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells

The purinergic P2X7 receptor (P2X7R) belongs to a family of trimeric ion channels that are gated by extracellular adenosine 5′-triphosphate (ATP). Several studies have pointed to a role of P2X7R-dependent signalling in Parkinson's disease (PD)-related neurodegeneration. The pathology of (PD) is...

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Bibliographic Details
Main Authors: Anna Wilkaniec, Magdalena Cieślik, Emilia Murawska, Lidia Babiec, Magdalena Gąssowska-Dobrowolska, Ewelina Pałasz, Henryk Jęśko, Agata Adamczyk
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
-synuclein
P2X7 receptor
mitochondria dysfunction
parkin
AMP-activated protein kinase
Online Access:https://www.mdpi.com/1422-0067/21/11/3959

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