Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells

Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells

Murphy Roths Large (MRL) mice possess outstanding capacity to regenerate several tissues. In the present study, we investigated whether this regenerative potential could be associated with the intrinsic particularities possessed by their mesenchymal stem cells (MSCs). We demonstrated that MSCs deriv...

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Bibliographic Details
Main Authors: Gautier Tejedor, Rafael Contreras-Lopez, Audrey Barthelaix, Maxime Ruiz, Danièle Noël, Frédéric De Ceuninck, Philippe Pastoureau, Patricia Luz-Crawford, Christian Jorgensen, Farida Djouad
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
MRL mouse
regeneration
mesenchymal stem cells
PYCR1
metabolism
chondrogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.604756/full

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