Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold selectivity for GluN2C/2D compared to GluN2A.
Bibliographic Details
| Main Authors: |
Jue Xiang Wang,
Mark W. Irvine,
Erica S. Burnell,
Kiran Sapkota,
Robert J. Thatcher,
Minjun Li,
Noriko Simorowski,
Arturas Volianskis,
Graham L. Collingridge,
Daniel T. Monaghan,
David E. Jane,
Hiro Furukawa |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14321-0
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