Direct Nucleophilic Difluoromethylation of Aromatic Isoxazoles Activated by Electron-Withdrawing Groups Using (Difluoromethyl)trimethylsilane
The activation of aromatic diaryl isoxazoles with strong electron-withdrawing groups, such as the nitro, triflyl and the phenylsulfonyl groups, at the 4-position has enabled the first regio- and diastereoselective difluoromethylation at the 5-position of isoxazoles by nucleophilic addition using (di...
| Format: | Article |
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| Language: | English |
| Published: |
ScienceOpen
2014-11-01
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| Series: | ScienceOpen Research |
| Online Access: | https://www.scienceopen.com/document?vid=381e3013-939e-4fd2-8af1-6ea99ba6d8a9 |