Kinetic Characterization of a Panel of High-Affinity Monoclonal Antibodies Targeting Ricin and Recombinant Re-Formatting for Biosensor Applications

Kinetic Characterization of a Panel of High-Affinity Monoclonal Antibodies Targeting Ricin and Recombinant Re-Formatting for Biosensor Applications

Ricin is a potent glycoprotein toxin that is structurally composed of two subunits joined via a disulfide bond: a ~30 kDa subunit A (RTA) and a ~32 kDa subunit B (RTB). There are fears of ricin being used as a weapon for warfare and terrorism and, as such, there is an increasing need for the develop...

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Bibliographic Details
Main Authors: Michelle Cummins, Con Dogovski, Remy Robert, Malcolm Alderton, Damien Chong, David Proll, Luisa Pontes-Braz, Anna Raicevic, Meghan Hattarki, Stewart Nuttall, Olan Dolezal
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Antibodies
Subjects:
monoclonal antibody
ricin
Fab fragment
SPR
epitope binning
Online Access:http://www.mdpi.com/2073-4468/3/2/215

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