Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and ext...

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Main Authors:	Mubeen M. Mosaheb, Elena Y. Dobrikova, Michael C. Brown, Yuanfan Yang, Jana Cable, Hideho Okada, Smita K. Nair, Darell D. Bigner, David M. Ashley, Matthias Gromeier
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13939-z

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spelling	doaj-9ce93ce8bbd34e53a699a9500f6bbbbf2021-05-11T09:15:09ZengNature Publishing GroupNature Communications2041-17232020-01-0111111510.1038/s41467-019-13939-zGenetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunityMubeen M. Mosaheb0Elena Y. Dobrikova1Michael C. Brown2Yuanfan Yang3Jana Cable4Hideho Okada5Smita K. Nair6Darell D. Bigner7David M. Ashley8Matthias Gromeier9Department of Molecular Genetics & Microbiology, Duke University Medical SchoolDepartment of Neurosurgery, Duke University Medical SchoolDepartment of Neurosurgery, Duke University Medical SchoolDepartment of Pathology, Duke University Medical SchoolDepartment of Molecular Genetics & Microbiology, Duke University Medical SchoolParker Institute for Cancer Immunotherapy, University of California at San FranciscoDepartment of Surgery, Duke University Medical SchoolDepartment of Neurosurgery, Duke University Medical SchoolDepartment of Neurosurgery, Duke University Medical SchoolDepartment of Molecular Genetics & Microbiology, Duke University Medical SchoolExperimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice.https://doi.org/10.1038/s41467-019-13939-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mubeen M. Mosaheb Elena Y. Dobrikova Michael C. Brown Yuanfan Yang Jana Cable Hideho Okada Smita K. Nair Darell D. Bigner David M. Ashley Matthias Gromeier
spellingShingle	Mubeen M. Mosaheb Elena Y. Dobrikova Michael C. Brown Yuanfan Yang Jana Cable Hideho Okada Smita K. Nair Darell D. Bigner David M. Ashley Matthias Gromeier Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity Nature Communications
author_facet	Mubeen M. Mosaheb Elena Y. Dobrikova Michael C. Brown Yuanfan Yang Jana Cable Hideho Okada Smita K. Nair Darell D. Bigner David M. Ashley Matthias Gromeier
author_sort	Mubeen M. Mosaheb
title	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_short	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_full	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_fullStr	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_full_unstemmed	Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity
title_sort	genetically stable poliovirus vectors activate dendritic cells and prime antitumor cd8 t cell immunity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Experimental PVSRIPO oncolytic virus therapy of glioblastoma has shown long-term efficacy in a subset of patients. Here the authors engineer the virus to enable incorporation of tumor-specific antigens, and show proof-of-principle evidence that this modification increases anti-tumor immunity and extends survival in mice.
url	https://doi.org/10.1038/s41467-019-13939-z
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Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity

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