Apelin-13 attenuates high glucose-induced calcification of MOVAS cells by regulating MAPKs and PI3K/AKT pathways and ROS-mediated signals

Apelin-13 attenuates high glucose-induced calcification of MOVAS cells by regulating MAPKs and PI3K/AKT pathways and ROS-mediated signals

Vascular calcification (VC) is an inducement of many cardiovascular diseases. Clinic evidences have confirmed that diabetes was the independent risk factor for VC, and the mechanism has not been well explored. Apelin as a ligand molecule is widely found in the cardiovascular system and showed potent...

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Bibliographic Details
Main Authors: Pu Zhang, Ai-ping Wang, Hong-peng Yang, Lei Ai, Hong-jun Zhang, Yong-mei Wang, Yan-ling Bi, Huai-hai Fan, Jing Gao, Huan-yi Zhang, Jian-zhu Liu
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Vascular calcification
Apelin-13
Alkaline phosphatase
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220304637

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