Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development

Abstract Background CHD8 haploinsufficiency causes autism and macrocephaly with high penetrance in the human population. Chd8 heterozygous mice exhibit relatively subtle brain overgrowth and little gene expression changes in the embryonic neocortex. The purpose of this study was to generate new, sub...

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Bibliographic Details
Main Authors: Shaun Hurley, Conor Mohan, Philipp Suetterlin, Robert Ellingford, Kimberley L. H. Riegman, Jacob Ellegood, Angela Caruso, Caterina Michetti, Olivier Brock, Romy Evans, Fabrizio Rudari, Alessio Delogu, Maria Luisa Scattoni, Jason P. Lerch, Cathy Fernandes, M. Albert Basson
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Autism
Subjects:
CHD8
Chromatin
TBR2
Autism
Cortex
Hypomorph
Online Access:https://doi.org/10.1186/s13229-020-00409-3

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