Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy.

Analysis of the fibroblast growth factor system reveals alterations in a mouse model of spinal muscular atrophy.

The monogenetic disease Spinal Muscular Atrophy (SMA) is characterized by a progressive loss of motoneurons leading to muscle weakness and atrophy due to severe reduction of the Survival of Motoneuron (SMN) protein. Several models of SMA show deficits in neurite outgrowth and maintenance of neuromus...

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Bibliographic Details
Main Authors: Niko Hensel, Andreas Ratzka, Hella Brinkmann, Lars Klimaschewski, Claudia Grothe, Peter Claus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3278439?pdf=render

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