Tuning Natural Killer Cell Anti-multiple Myeloma Reactivity by Targeting Inhibitory Signaling via KIR and NKG2A

Tuning Natural Killer Cell Anti-multiple Myeloma Reactivity by Targeting Inhibitory Signaling via KIR and NKG2A

Natural killer (NK) cells are attractive candidates for allogeneic cell-based immunotherapy due to their potent antitumor effector function and good safety profile. NK cells express killer immunoglobulin-like receptors (KIRs) and the NKG2A receptor important for NK cells education as well as providi...

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Bibliographic Details
Main Authors: Niken M. Mahaweni, Femke A. I. Ehlers, Gerard M. J. Bos, Lotte Wieten
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
NK cell
NKG2A
KIR
HLA class I
HLA-E
multiple myeloma
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02848/full

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