Biological Functions of the Intrinsically Disordered N-Terminal Domain of the Prion Protein: A Possible Role of Liquid–Liquid Phase Separation

Biological Functions of the Intrinsically Disordered N-Terminal Domain of the Prion Protein: A Possible Role of Liquid–Liquid Phase Separation

The mammalian prion protein (PrP<sup>C</sup>) is composed of a large intrinsically disordered N-terminal and a structured C-terminal domain, containing three alpha-helical regions and a short, two-stranded beta-sheet. Traditionally, the activity of a protein was linked to the ability of...

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Bibliographic Details
Main Authors: Stella A. Polido, Janine Kamps, Jörg Tatzelt
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomolecules
Subjects:
prion
intrinsically disordered
stress protection
liquid–liquid phase separation
neurodegeneration
Online Access:https://www.mdpi.com/2218-273X/11/8/1201

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