Epigenetic Characteristics of Human Subtelomeres Vary in Cells Utilizing the Alternative Lengthening of Telomeres (ALT) Pathway

Epigenetic Characteristics of Human Subtelomeres Vary in Cells Utilizing the Alternative Lengthening of Telomeres (ALT) Pathway

Most human cancers circumvent senescence by activating a telomere length maintenance mechanism, most commonly involving telomerase activation. A minority of cancers utilize the recombination-based alternative lengthening of telomeres (ALT) pathway. The exact requirements for unleashing normally repr...

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Bibliographic Details
Main Authors: Shir Toubiana, Aya Tzur-Gilat, Sara Selig
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Life
Subjects:
alternative lengthening of telomeres (ALT)
telomere
subtelomere
DNA methylation
TERRA
H3K4me3
Online Access:https://www.mdpi.com/2075-1729/11/4/278

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