Study of Nitrosative Stress in ‘Pregnancy Induced Hypertension’

• Main Authors: Kapila B Gaikwad, Nitin G Joshi, Sohan P Selkar
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2017-03-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: free radical; nitric oxide; nitrothiol; thiol
• Online Access: https://jcdr.net/articles/PDF/9396/23960_CE[Ra1]_F(DK)_PF1(P_RK)_PFA(DK)_PF2(NE_SY_DK).pdf

Introduction: Hypertension is the most common medical problem encountered during pregnancy. Pregnancy Induced Hypertension (PIH) is also called a disease of maternal endothelium. Nitric-oxide being a potent vasodilator released by endothelial cells, its role has been implicated in PIH. Aim: To study the role of reactive nitrogen species in PIH. Materials and Methods: One hundred and twenty samples were selected for the study. Of these, 60 patients had PIH (case) and the rest without PIH (control). Estimation of serum nitricoxide, serum nitrothiol, serum total thiol was done. Results: The study showed decreased NOx (Mono nitrogen oxide No and No2 ) levels in PIH as compared to control (p< 0.001). PIH patients had significantly higher levels of S-nitrothiols than control (p<0.01). Thiol levels were decreased in PIH as compared to control (p<0.001) Conclusion: Thus, it is concluded from this study that nitrosative stress represents a point of convergence for several contributing factors potentially leading to the clinical manifestations of pregnancy induced hypertension. The antioxidants are used up while scavenging the free radicals.