Dysregulation of Alternative Poly-adenylation as a Potential Player in Autism Spectrum Disorder

Dysregulation of Alternative Poly-adenylation as a Potential Player in Autism Spectrum Disorder

We present here the hypothesis that alternative poly-adenylation (APA) is dysregulated in the brains of individuals affected by Autism Spectrum Disorder (ASD), due to disruptions in the calcium signaling networks. APA, the process of selecting different poly-adenylation sites on the same gene, yield...

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Bibliographic Details
Main Authors: Krzysztof J. Szkop, Peter I. C. Cooke, Joanne A. Humphries, Viktoria Kalna, David S. Moss, Eugene F. Schuster, Irene Nobeli
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
autism spectrum disorder
alternative poly-adenylation
RNA–seq
calcium signaling
transcription
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00279/full

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