Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats

Kynurenic Acid and Its Synthetic Derivatives Protect Against Sepsis-Associated Neutrophil Activation and Brain Mitochondrial Dysfunction in Rats

Background and AimsThe systemic host response in sepsis is frequently accompanied by central nervous system (CNS) dysfunction. Evidence suggests that excessive formation of neutrophil extracellular traps (NETs) can increase the permeability of the blood–brain barrier (BBB) and that the evolving mito...

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Main Authors: Marietta Z. Poles, Anna Nászai, Levente Gulácsi, Bálint L. Czakó, Krisztián G. Gál, Romy J. Glenz, Dishana Dookhun, Attila Rutai, Szabolcs P. Tallósy, Andrea Szabó, Bálint Lőrinczi, István Szatmári, Ferenc Fülöp, László Vécsei, Mihály Boros, László Juhász, József Kaszaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
N-methyl-D-aspartate receptor
blood-brain barrier
mitochondrial respiration
brain injury
neutrophil extracellular trap
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.717157/full

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