Eupatilin Promotes Cell Death by Calcium Influx through ER-Mitochondria Axis with SERPINB11 Inhibition in Epithelial Ovarian Cancer

Eupatilin Promotes Cell Death by Calcium Influx through ER-Mitochondria Axis with SERPINB11 Inhibition in Epithelial Ovarian Cancer

Ovarian cancer is the leading cause of gynecological cancer-related mortality. The anticancer effect of eupatilin, a family of flavonoids, is known in many cancer types, but it is unclear what mechanism it plays in ovarian cancer. In this study, eupatilin promoted cell death of ovarian cancer cells...

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Bibliographic Details
Main Authors: Jin-Young Lee, Hyocheol Bae, Changwon Yang, Sunwoo Park, Byung-Soo Youn, Han-Soo Kim, Gwonhwa Song, Whasun Lim
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
SERPINB11
ovarian cancer
eupatilin
calcium influx
ER–mitochondria axis
Online Access:https://www.mdpi.com/2072-6694/12/6/1459

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