Clinical and Laboratory Evaluation of Patients Diagnosed with COVID-19 Receiving Favipiravir-based Treatment

• Main Authors: Burak SARIKAYA, Semiha ÇELİK EKİNCİ
• Format: Article
• Language: English
• Published: Galenos Publishing House 2020-12-01
• Series: Bezmiâlem Science
• Subjects: covid-19; favipirovir; mortality
• Online Access: http://bezmialemscience.org/archives/archive-detail/article-preview/clinical-and-laboratory-evaluation-of-patients-dia/42775

Objective:Severe acute respiratory syndrome coronavirus-2 (SARS COV-2); can lead to severe respiratory failure. In this study, factors affecting mortality in Coronavirus disease (COVID-19) patients who were hospitalized with hydroxychloroquine (HCQ), azithromycin and favipiravir treatments were investigated.Methods:Between March 10 and May 10, 2020, COVID-19 reverse transcription polymerase chain reaction (RT-PCR) positive treatment naive 683 patients were screened retrospectively. Five hundred four patients were followed without treatment or with HCQ treatment. Out of 179 patients, 137 were hospitalized and 42 were directly admitted to the intensive care unit (ICU). Oxygen saturation of these patients is <90%, follow-up (>30/min) and HCQ, azithromycin, favipiravir were started. 35 of 137 patients were transferred to ICU. Mechanical ventilation was provided to 69 (89%) of 77 patients in the ICU. 19 (24%) patients received tosilizumab and 13 (17%) patients received immune plasma. It was divided into two as healing and exitus. Demographic features, comorbid diseases, secondary bacterial infections and acute organ damage were recorded.Results:Two hundred of the patients were male and their average age was 60.9±16.4 years. HT and diabetes mellitus (DM) were the most common comorbid disease. Acute liver injury was most common. 54 patients became exitus. Exitus group has higher mean age, chronic heart disease (CHD), DM, CRF, acute cardiac damage and secondary bacterial infection are more statistically significant (p<0.05). Exitus status DM 2.17, COPD 2.18, asthma 3.01, CHD 2.4, CRF 8.3, malignancy 1.6, acute cardiac damage 12.9, secondary bacterial infection development 3.63 times mortality increase statistically significant (p<0.05).Conclusion:In patients receiving treatment based on Favipiravir; advanced age, DM, CHD, CKD, troponin-I elevation and secondary bacterial infections are associated with mortality. CRF and troponin-I elevation are predictors of mortality.