In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required. Interfering with Quorum Sensing (QS), a cell-to-cell communication system, has s...

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Bibliographic Details
Main Authors: Giuseppe Allegretta, Christine K. Maurer, Jens Eberhard, Damien Maura, Rolf W. Hartmann, Laurence Rahme, Martin Empting
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Microbiology
Subjects:
Pseudomonas aeruginosa
quinolones
2′-aminoacetophenone
dihydroxyquinoline
persistence
Quorum Sensing Inhibitors
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00924/full

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