Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer’s Disease Risk Reveal a Potential Role for SIGLEC14

Analysis of Genetic Variants Associated with Levels of Immune Modulating Proteins for Impact on Alzheimer’s Disease Risk Reveal a Potential Role for SIGLEC14

Genome-wide association studies (GWAS) have identified immune-related genes as risk factors for Alzheimer’s disease (AD), including <i>TREM2</i> and <i>CD33</i>, frequently passing a stringent false-discovery rate. These genes either encode or signal through immunomodulatory...

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Bibliographic Details
Main Authors: Benjamin C. Shaw, Yuriko Katsumata, James F. Simpson, David W. Fardo, Steven Estus
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Genes
Subjects:
ITIM
ITAM
<i>SIGLEC14</i>
<i>SIGLEC5</i>
copy number variation
CNV
Online Access:https://www.mdpi.com/2073-4425/12/7/1008

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