Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays

Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays

Abstract Background Malaria in pregnancy is a major cause of poor maternal and infant health, and is associated with the sequestration of P. falciparum-infected erythrocytes (IE) in the placenta. The leading vaccine candidate for pregnancy malaria, VAR2CSA, has been shown to induce antibodies that i...

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Bibliographic Details
Main Authors: Mirja Hommel, Jo-Anne Chan, Alexandra J. Umbers, Christine Langer, Stephen J. Rogerson, Joseph D. Smith, James G. Beeson
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Parasites & Vectors
Subjects:
Malaria in pregnancy
Placental malaria
Vaccines
Immunity
Opsonic phagocytosis
Online Access:http://link.springer.com/article/10.1186/s13071-018-2653-7

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http://link.springer.com/article/10.1186/s13071-018-2653-7

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