5-methoxytryptophan: an arsenal against vascular injury and inflammation

5-methoxytryptophan: an arsenal against vascular injury and inflammation

Abstract 5-methoxytryptophan (5-MTP) is an endothelial factor with anti-inflammatory properties. It is synthesized from L-tryptophan via two enzymatic steps: tryptophan hydroxylase-1 (TPH-1) and hydroxyindole O-methyltransferase. Lipopolysaccharide (LPS) and pro-inflammatory cytokines suppress endot...

Full description

Bibliographic Details
Main Authors:	Kenneth K. Wu, Cheng-Chin Kuo, Shaw-Fang Yet, Chii-Ming Lee, Jun-Yang Liou
Format:	Article
Language:	English
Published:	BMC 2020-07-01
Series:	Journal of Biomedical Science
Subjects:	5-methoxytryptophan Tryptophan hydroxylase-1 Hydroxyindole O-methyltransferase Intimal hyperplasia Endothelial barrier function Smooth muscle cell migration and proliferation
Online Access:	http://link.springer.com/article/10.1186/s12929-020-00671-w

Similar Items

Molecular Action of Hydroxytyrosol in Attenuation of Intimal Hyperplasia: A Scoping Review
by: Ubashini Vijakumaran, et al.
Published: (2021-05-01)

The role of 5-methoxytryptophan in pediatric-onset lupus nephritis: A retrospective cohort study
by: Ting-Chun Lin, et al.
Published: (2020-10-01)

lncRNA KCNQ1OT1 Suppresses the Inflammation and Proliferation of Vascular Smooth Muscle Cells through IκBa in Intimal Hyperplasia
by: Bozhi Ye, et al.
Published: (2020-06-01)

tRNA-derived fragments tRFGlnCTG induced by arterial injury promote vascular smooth muscle cell proliferation
by: Xiao-Ling Zhu, et al.
Published: (2021-03-01)

Targeting smooth muscle cell phenotypic switching in vascular disease
by: Raja Chakraborty, PhD, et al.
Published: (2021-01-01)

Opposing Effects on Vascular Smooth Muscle Cell Proliferation and Macrophage-induced Inflammation Reveal a Protective Role for the Proresolving Lipid Mediator Receptor ChemR23 in Intimal Hyperplasia
by: Gonzalo Artiach, et al.
Published: (2018-11-01)

5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders
by: Hridya Jayamohananan, et al.
Published: (2019-08-01)

Effect of N-acetylcysteine on intimal hyperplasia and endothelial proliferation in rabbit carotid artery anastomosis
by: Ali Kavala, et al.
Published: (2018-08-01)

BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries
by: Bowen Wang, et al.
Published: (2015-11-01)

Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase
by: Zachary W.Q. Moore, et al.
Published: (2005-10-01)

Challenges and strategies for in situ endothelialization and long-term lumen patency of vascular grafts
by: Yu Zhuang, et al.
Published: (2021-06-01)

SIMVASTATIN INCORPORATED PERIVASCULAR POLYMERIC CONTROLLED DRUG DELIVERY SYSTEM FOR THE INHIBITION OF VASCULAR WALL INTIMAL HYPERPLASIA
by: Krishnan, Aadithya
Published: (2007)

Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury
by: Andrew H. Smith, MD, et al.
Published: (2020-01-01)

Serotonin stimulates Echinococcus multilocularis larval development
by: Michaela Herz, et al.
Published: (2021-01-01)

Vascular effects of tryptophan
by: Gandhi, Jugal Daxesh
Published: (2010)

Platelet-Derived Microvesicles Promote VSMC Dedifferentiation After Intimal Injury via Src/Lamtor1/mTORC1 Signaling
by: Ji-Ting Liu, et al.
Published: (2021-09-01)

Immune Mechanisms of Extracellular Matrix Remodeling in the Common Carotid: A Model of Intimal Hyperplasia
by: Robb, Tiffany Marie
Published: (2012)

Synthesis, evaluation, and applications of hydrogen sulfide-releasing supramolecular materials
by: Kaur, Kuljeet
Published: (2021)

Urea Derivative Catalyzed Enantioselective Hydroxyalkylation of Hydroxyindoles with Isatins
by: Hao Wu, et al.
Published: (2019-10-01)

Cytoguardin: A Tryptophan Metabolite against Cancer Growth and Metastasis
by: Kenneth K. Wu
Published: (2021-04-01)

Salvianolic Acid A Inhibits PDGF-BB Induced Vascular Smooth Muscle Cell Migration and Proliferation While Does Not Constrain Endothelial Cell Proliferation and Nitric Oxide Biosynthesis
by: Chao Huang, et al.
Published: (2012-03-01)

Influence of ischemia before vein grafting on early hyperplasia of the graft and the dynamic changes of the intima after grafting
by: Zou RongJiang, et al.
Published: (2012-09-01)

Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate
by: Denise Burtenshaw, et al.
Published: (2017-11-01)

Rat brain serotonin synthesis under prolonged consumption of fructose solution
by: T. P. Karpovets, et al.
Published: (2014-12-01)

Cloning, expression and partial characterization of tryptophan hydroxylase in Caenorhabditis elegans
by: Hill, Suzanne Deborah.
Published: (1998)

The Protective Effect of Bcl-xl Overexpression against Oxidative Stress-Induced Vascular Endothelial Cell Injury and the Role of the Akt/eNOS Pathway
by: Changwei Liu, et al.
Published: (2013-11-01)

Selective Inhibitory Effect of Epigallocatechin-3-gallate on Migration of Vascular Smooth Muscle Cells
by: Jong-Chul Park, et al.
Published: (2010-11-01)

Oxygen Regulation of Vascular Smooth Muscle Cell Proliferation and Survival
by: Basu Ray, Julie
Published: (2009)

Oxygen Regulation of Vascular Smooth Muscle Cell Proliferation and Survival
by: Basu Ray, Julie
Published: (2009)

The Role of Serotonin (5-HT) in Regulating the Hypoxic Hyperventilatory Response of Larval Zebrafish
by: Jensen, Gregory
Published: (2016)

Serotonin biosynthesis and receptors in helminths
by: Hamdan, Fadi F.
Published: (2000)

All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK Signaling Pathway
by: Jingzhi Zhang, et al.
Published: (2019-05-01)

Dysregulation of the Mammalian Target of Rapamycin and p27Kip1 Promotes Intimal Hyperplasia in Diabetes Mellitus
by: Thomas Cooper Woods
Published: (2013-05-01)

Editorial: Intra/Extracellular Dynamics of the Respiratory System and Global Airway Disease
by: Wei-jie Guan, et al.
Published: (2020-07-01)

sibs of Iraqi families affected by congenital adrenal hyperplasia
by: Rafia Al-Rawi, et al.
Published: (2006-07-01)

Airway remodeling disease: primary human structural cells and phenotypic and pathway assays to identify targets with potential to prevent or reverse remodeling
by: Rosethorne EM, et al.
Published: (2018-11-01)

SIRT1 and Connexin40 Mediate the Normal Shear Stress-Induced Inhibition of the Proliferation of Endothelial Cells Co-Cultured with Vascular Smooth Muscle Cells
by: Qing-Ping Yao, et al.
Published: (2013-03-01)

RhoGTPase in Vascular Disease
by: Derek Strassheim, et al.
Published: (2019-06-01)

5-Hydroxyindole-Based EZH2 Inhibitors Assembled via TCCA-Catalyzed Condensation and Nenitzescu Reactions
by: Fangyu Du, et al.
Published: (2020-04-01)

Polymorphism of TPH2 gene rs120074175 is not associated with risk factors of schizophrenia
by: James P Laksono, et al.
Published: (2019-01-01)