The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy, senescence, proliferation, aging, and tumorigenesis. It also has a key role in the epigenetic regulation of tissue homeostasis...

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Bibliographic Details
Main Authors:	Débora Kristina Alves-Fernandes, Miriam Galvonas Jasiulionis
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	International Journal of Molecular Sciences
Subjects:	SIRT1 DNA damage/repair epigenetics cancer development
Online Access:	https://www.mdpi.com/1422-0067/20/13/3153

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