Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

In bacteria, the DnaG primase is responsible for synthesis of short RNA primers used to initiate chain extension by replicative DNA polymerase(s) during chromosomal replication. Among the proteins with which Escherichia coli DnaG interacts is the single-stranded DNA-binding protein, SSB. The C-termi...

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Bibliographic Details
Main Authors: Zorik Chilingaryan, Stephen J. Headey, Allen T. Y. Lo, Zhi-Qiang Xu, Gottfried Otting, Nicholas E. Dixon, Martin J. Scanlon, Aaron J. Oakley
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Antibiotics
Subjects:
antibacterial agents
fragment-based screening
primase
protein–protein interactions
SSB
Online Access:http://www.mdpi.com/2079-6382/7/1/14

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