Necrotising retinopathy-like lesions as a manifestation of ocular sarcoidosis

• Main Authors: Florence Rasquin, Nacima Kisma, Laure Van Bol
• Format: Article
• Language: English
• Published: SpringerOpen 2018-08-01
• Series: Journal of Ophthalmic Inflammation and Infection
• Subjects: Necrotising; Retinopathy; Sarcoidosis; Lymphoproliferative; Virus
• Online Access: http://link.springer.com/article/10.1186/s12348-018-0154-7

Abstract Background A 56-year-old Caucasian man presented with a 2-weeks history of decreased vision in the right eye. Vitritis, papillitis, cystoid macular oedema and inferior diffuse retinal infiltration were noticed. Extensive blood work-up, anterior chamber paracentesis with polymerase chain reaction (PCR) and Goldmann-Witmer coefficient, tuberculin skin test (PPD-test), fluorodeoxyglucose Positron Emission Tomography CT scan (FDG-PET/CT), lymph node biopsy and pars plana vitrectomy were performed. Results Aqueous and vitreous samples were negative for an infectious and a lymphoproliferative etiology. Enlarged hilar and mediastinal lymph nodes were detected by FDG-PET/CT and subsequently biopsied, allowing to confirm the diagnosis of sarcoidosis. After a few months of oral corticosteroid therapy, the inflammation resolved completely and was replaced by atrophic retinal scars. Conclusion Necrotising retinopathy-like lesions mimicking an infectious process or a lymphoproliferative disorder can be an atypical manifestation of ocular sarcoidosis.