Prophage induction is enhanced and required for renal disease and lethality in an EHEC mouse model.
Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. A...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-03-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC3610611?pdf=render |