microRNA-34a (miRNA-34a) Mediated Down-Regulation of the Post-synaptic Cytoskeletal Element SHANK3 in Sporadic Alzheimer's Disease (AD)

microRNA-34a (miRNA-34a) Mediated Down-Regulation of the Post-synaptic Cytoskeletal Element SHANK3 in Sporadic Alzheimer's Disease (AD)

Integrating a combination of bioinformatics, microRNA microfluidic arrays, ELISA analysis, LED Northern, and transfection-luciferase reporter assay data using human neuronal-glial (HNG) cells in primary culture we have discovered a set of up-regulated microRNAs (miRNAs) linked to a small family of d...

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Bibliographic Details
Main Authors: Yuhai Zhao, Vivian R. Jaber, Ayrian LeBeauf, Nathan M. Sharfman, Walter J. Lukiw
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Neurology
Subjects:
Alzheimer's disease (AD)
miRNA-34a
neurotransmission
post-synaptic density proteins
SHANK3 protein
superior temporal lobe neocortex (Brodmann A22)
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00028/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.00028/full

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