PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice

Jingliang Zhang et al. examine how dysfunctional PKA signaling impacts neuronal activity and seizure susceptibility in a mouse model of temporal lobe epilepsy. Their data suggest that autophosphorylation of the RIIβ subunit regulates neuronal excitability, and may act as a future therapeutic target....

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Bibliographic Details
Main Authors:	Jingliang Zhang, Chenyu Zhang, Xiaoling Chen, Bingwei Wang, Weining Ma, Yang Yang, Ruimao Zheng, Zhuo Huang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-03-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-021-01748-4

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