Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

Aggregation of α-synuclein (α-syn) is neuropathologically and genetically linked to Parkinson's disease (PD). Since stereotypic cell-to-cell spreading of α-syn pathology is believed to contribute to disease progression, immunotherapy with antibodies directed against α-syn is considered a promis...

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Bibliographic Details
Main Authors: Andreas Weihofen, YuTing Liu, Joseph W. Arndt, Christian Huy, Chao Quan, Benjamin A. Smith, Jean-Luc Baeriswyl, Nicole Cavegn, Luzia Senn, Lihe Su, Galina Marsh, Pavan K. Auluck, Fabio Montrasio, Roger M. Nitsch, Warren D. Hirst, Jesse M. Cedarbaum, R. Blake Pepinsky, Jan Grimm, Paul H. Weinreb
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Subjects:
Alpha-synuclein
Parkinson's disease
Lewy Bodies
Immunotherapy
BIIB054
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118304480

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