Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa
Sirtuin 1 (SIRT1) is a sensor of cell energy availability, and with leptin and adiponectin, it regulates metabolic homeostasis. Widely studied in tissues, SIRT1 is under evaluation as a plasmatic marker. We aimed at assessing whether circulating SIRT1 behaves consistently with leptin and adiponectin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/11/3506 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Stefania Mariani Maria Rosaria Di Giorgio Erica Rossi Rossella Tozzi Savina Contini Lisa Bauleo Fiammetta Cipriani Raffaella Toscano Sabrina Basciani Giuseppe Barbaro Mikiko Watanabe Agostino Valenti Armando Cotugno Carla Ancona Carla Lubrano Lucio Gnessi |
| spellingShingle |
Stefania Mariani Maria Rosaria Di Giorgio Erica Rossi Rossella Tozzi Savina Contini Lisa Bauleo Fiammetta Cipriani Raffaella Toscano Sabrina Basciani Giuseppe Barbaro Mikiko Watanabe Agostino Valenti Armando Cotugno Carla Ancona Carla Lubrano Lucio Gnessi Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa Nutrients adipose tissue sirtuins plasma SIRT1 adiponectin leptin anorexia nervosa |
| author_facet |
Stefania Mariani Maria Rosaria Di Giorgio Erica Rossi Rossella Tozzi Savina Contini Lisa Bauleo Fiammetta Cipriani Raffaella Toscano Sabrina Basciani Giuseppe Barbaro Mikiko Watanabe Agostino Valenti Armando Cotugno Carla Ancona Carla Lubrano Lucio Gnessi |
| author_sort |
Stefania Mariani |
| title |
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa |
| title_short |
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa |
| title_full |
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa |
| title_fullStr |
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa |
| title_full_unstemmed |
Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa |
| title_sort |
blood sirt1 shows a coherent association with leptin and adiponectin in relation to the degree and distribution of adiposity: a study in obesity, normal weight and anorexia nervosa |
| publisher |
MDPI AG |
| series |
Nutrients |
| issn |
2072-6643 |
| publishDate |
2020-11-01 |
| description |
Sirtuin 1 (SIRT1) is a sensor of cell energy availability, and with leptin and adiponectin, it regulates metabolic homeostasis. Widely studied in tissues, SIRT1 is under evaluation as a plasmatic marker. We aimed at assessing whether circulating SIRT1 behaves consistently with leptin and adiponectin in conditions of deficiency, excess or normal fat content. Eighty subjects were evaluated: 27 with anorexia nervosa (AN), 26 normal-weight and 27 with obesity. Bloodstream SIRT1, leptin and adiponectin (ELISA), total and trunk fat mass (FM) %, abdominal visceral adipose tissue, liver steatosis and epicardial fat thickness (EFT) were assessed. For each fat store, the coefficient of determination (R<sup>2</sup>) was used to evaluate the prediction capability of SIRT1, leptin and adiponectin. Plasma SIRT1 and adiponectin coherently decreased with the increase of FM, while the opposite occurred with leptin. Mean levels of each analyte were different between groups (<i>p</i> < 0.005). A significant association between plasma variables and FM depots was observed. SIRT1 showed a good predictive strength for FM, particularly in the obesity group, where the best R<sup>2</sup> was recorded for EFT (R<sup>2</sup> = 0.7). Blood SIRT1, adiponectin and leptin behave coherently with FM and there is synchrony between them. The association of SIRT1 with FM is substantially superimposable to that of adiponectin and leptin. Given its homeostatic roles, SIRT1 may deserve to be considered as a plasma clinical/biochemical parameter of adiposity and metabolic health. |
| topic |
adipose tissue sirtuins plasma SIRT1 adiponectin leptin anorexia nervosa |
| url |
https://www.mdpi.com/2072-6643/12/11/3506 |
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doaj-9c2cc8205ebc40feaac8988662df025a2020-11-25T03:59:37ZengMDPI AGNutrients2072-66432020-11-01123506350610.3390/nu12113506Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia NervosaStefania Mariani0Maria Rosaria Di Giorgio1Erica Rossi2Rossella Tozzi3Savina Contini4Lisa Bauleo5Fiammetta Cipriani6Raffaella Toscano7Sabrina Basciani8Giuseppe Barbaro9Mikiko Watanabe10Agostino Valenti11Armando Cotugno12Carla Ancona13Carla Lubrano14Lucio Gnessi15Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Molecular Medicine, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Epidemiology, Lazio Regional Health Service, 00147 Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyInternal Medicine, Santo Spirito in Sassia Hospital, 00193 Rome, ItalyDepartment of Mental Health, UOSD eating behavior disorders, Padiglione I, Comprensorio S. Maria della Pietà, 00135 Rome, ItalyDepartment of Epidemiology, Lazio Regional Health Service, 00147 Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalyDepartment of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, ItalySirtuin 1 (SIRT1) is a sensor of cell energy availability, and with leptin and adiponectin, it regulates metabolic homeostasis. Widely studied in tissues, SIRT1 is under evaluation as a plasmatic marker. We aimed at assessing whether circulating SIRT1 behaves consistently with leptin and adiponectin in conditions of deficiency, excess or normal fat content. Eighty subjects were evaluated: 27 with anorexia nervosa (AN), 26 normal-weight and 27 with obesity. Bloodstream SIRT1, leptin and adiponectin (ELISA), total and trunk fat mass (FM) %, abdominal visceral adipose tissue, liver steatosis and epicardial fat thickness (EFT) were assessed. For each fat store, the coefficient of determination (R<sup>2</sup>) was used to evaluate the prediction capability of SIRT1, leptin and adiponectin. Plasma SIRT1 and adiponectin coherently decreased with the increase of FM, while the opposite occurred with leptin. Mean levels of each analyte were different between groups (<i>p</i> < 0.005). A significant association between plasma variables and FM depots was observed. SIRT1 showed a good predictive strength for FM, particularly in the obesity group, where the best R<sup>2</sup> was recorded for EFT (R<sup>2</sup> = 0.7). Blood SIRT1, adiponectin and leptin behave coherently with FM and there is synchrony between them. The association of SIRT1 with FM is substantially superimposable to that of adiponectin and leptin. Given its homeostatic roles, SIRT1 may deserve to be considered as a plasma clinical/biochemical parameter of adiposity and metabolic health.https://www.mdpi.com/2072-6643/12/11/3506adipose tissuesirtuinsplasma SIRT1adiponectinleptinanorexia nervosa |