SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintain NMD activity by permitting SMG6 activation.

Bibliographic Details
Main Authors:	Volker Boehm, Sabrina Kueckelmann, Jennifer V. Gerbracht, Sebastian Kallabis, Thiago Britto-Borges, Janine Altmüller, Marcus Krüger, Christoph Dieterich, Niels H. Gehring
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24046-3

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spelling	doaj-9c2915beac40413f8c56308a467df5412021-06-27T11:12:07ZengNature Publishing GroupNature Communications2041-17232021-06-0112111910.1038/s41467-021-24046-3SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activityVolker Boehm0Sabrina Kueckelmann1Jennifer V. Gerbracht2Sebastian Kallabis3Thiago Britto-Borges4Janine Altmüller5Marcus Krüger6Christoph Dieterich7Niels H. Gehring8Institute for Genetics, University of CologneInstitute for Genetics, University of CologneInstitute for Genetics, University of CologneCECAD Research Center, University of CologneSection of Bioinformatics and Systems Cardiology, Department of Internal Medicine III and Klaus Tschira Institute for Integrative Computational Cardiology, Heidelberg University HospitalCologne Center for Genomics (CCG), University of CologneCenter for Molecular Medicine Cologne (CMMC), University of CologneSection of Bioinformatics and Systems Cardiology, Department of Internal Medicine III and Klaus Tschira Institute for Integrative Computational Cardiology, Heidelberg University HospitalInstitute for Genetics, University of CologneDegradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintain NMD activity by permitting SMG6 activation.https://doi.org/10.1038/s41467-021-24046-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Volker Boehm Sabrina Kueckelmann Jennifer V. Gerbracht Sebastian Kallabis Thiago Britto-Borges Janine Altmüller Marcus Krüger Christoph Dieterich Niels H. Gehring
spellingShingle	Volker Boehm Sabrina Kueckelmann Jennifer V. Gerbracht Sebastian Kallabis Thiago Britto-Borges Janine Altmüller Marcus Krüger Christoph Dieterich Niels H. Gehring SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity Nature Communications
author_facet	Volker Boehm Sabrina Kueckelmann Jennifer V. Gerbracht Sebastian Kallabis Thiago Britto-Borges Janine Altmüller Marcus Krüger Christoph Dieterich Niels H. Gehring
author_sort	Volker Boehm
title	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_short	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_full	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_fullStr	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_full_unstemmed	SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity
title_sort	smg5-smg7 authorize nonsense-mediated mrna decay by enabling smg6 endonucleolytic activity
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-06-01
description	Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly independent pathways, SMG6-mediated endonucleolytic cleavage and/or SMG5-SMG7-induced accelerated deadenylation. Here the authors show that SMG5-SMG7 maintain NMD activity by permitting SMG6 activation.
url	https://doi.org/10.1038/s41467-021-24046-3
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SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity

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