Current role of non-coding RNAs in the clinical setting

Current role of non-coding RNAs in the clinical setting

Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and pathological conditions. Mounting evidences have also shown that ncRNAs may serve as diagnostic mar...

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Main Authors: Caterina Vicentini, Francesca Galuppini, Vincenzo Corbo, Matteo Fassan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2019-09-01
Series:Non-coding RNA Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2468054019300265
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spelling doaj-9c2280f0b0814cf7bcccfda324bbef862021-04-02T14:41:27ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402019-09-01438285Current role of non-coding RNAs in the clinical settingCaterina Vicentini0Francesca Galuppini1Vincenzo Corbo2Matteo Fassan3ARC-NET Research Centre, University of Verona, Verona, ItalyDepartment of Medicine (DIMED), University of Padua, Padua, PD, ItalyARC-NET Research Centre, University of Verona, Verona, ItalyDepartment of Medicine (DIMED), University of Padua, Padua, PD, Italy; Corresponding author. Surgical Pathology and Cytopathology Unit - Department of Medicine (DIMED); University of Padua; via Gabelli 61, Padua, 35121, Italy.Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and pathological conditions. Mounting evidences have also shown that ncRNAs may serve as diagnostic markers for several disorders, predictor for drugs response, and targets for new therapeutic approaches. In this mini-review, we discuss the state of the art of non-coding RNAs in drug development and their involvement in conventional treatments response. Keywords: miRNAs, Non-coding RNAs, miRNA-based therapy, Drug resistancehttp://www.sciencedirect.com/science/article/pii/S2468054019300265
collection DOAJ
language English
format Article
sources DOAJ
author Caterina Vicentini
Francesca Galuppini
Vincenzo Corbo
Matteo Fassan
spellingShingle Caterina Vicentini
Francesca Galuppini
Vincenzo Corbo
Matteo Fassan
Current role of non-coding RNAs in the clinical setting
Non-coding RNA Research
author_facet Caterina Vicentini
Francesca Galuppini
Vincenzo Corbo
Matteo Fassan
author_sort Caterina Vicentini
title Current role of non-coding RNAs in the clinical setting
title_short Current role of non-coding RNAs in the clinical setting
title_full Current role of non-coding RNAs in the clinical setting
title_fullStr Current role of non-coding RNAs in the clinical setting
title_full_unstemmed Current role of non-coding RNAs in the clinical setting
title_sort current role of non-coding rnas in the clinical setting
publisher KeAi Communications Co., Ltd.
series Non-coding RNA Research
issn 2468-0540
publishDate 2019-09-01
description Non-coding RNAs (ncRNAs) have long been considered as “junk” material of the human genome until functional studies have exposed them as critical regulators of gene expression in both physiological and pathological conditions. Mounting evidences have also shown that ncRNAs may serve as diagnostic markers for several disorders, predictor for drugs response, and targets for new therapeutic approaches. In this mini-review, we discuss the state of the art of non-coding RNAs in drug development and their involvement in conventional treatments response. Keywords: miRNAs, Non-coding RNAs, miRNA-based therapy, Drug resistance
url http://www.sciencedirect.com/science/article/pii/S2468054019300265
work_keys_str_mv AT caterinavicentini currentroleofnoncodingrnasintheclinicalsetting
AT francescagaluppini currentroleofnoncodingrnasintheclinicalsetting
AT vincenzocorbo currentroleofnoncodingrnasintheclinicalsetting
AT matteofassan currentroleofnoncodingrnasintheclinicalsetting
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