Comparative Study of 5’- Nucleotidase Test in Various Liver Diseases
Introduction: The liver regulates many important metabolic functions. The 5’-nucleotidase activity is increased in obstructive jaundice, parenchymal liver disease, and hepatic metastases. Aim: This study was conducted to assess the serum levels of 5’-nucleotidase on patients with viral hepatitis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/7163/12754_CE[Ra1]_F(AK)_PF1(Ek_Om)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: The liver regulates many important metabolic
functions. The 5’-nucleotidase activity is increased in obstructive
jaundice, parenchymal liver disease, and hepatic metastases.
Aim: This study was conducted to assess the serum levels of
5’-nucleotidase on patients with viral hepatitis, alcoholic liver
diseases and liver cirrhosis, moreover to make comparison to
assess the degree of biliary involvement.
Materials and Methods: A total of 60 male subjects (15 healthy
controls and 45 case subjects) were enrolled, aged between 30
-50 years, each case group consisted of 15 male age-matched
patients suffering with viral hepatitis, alcoholic liver disease
(more than 10 years.) and liver cirrhosis.
Serum 5’-nucleotidase was analyzed as per the standard
laboratory procedure.
Results: The 5’-nucleotidase levels were significantly raised
in viral hepatitis, alcoholic liver disease and cirrhosis patients.
The levels being 35.2±8.43, 29.87±3.94, and 24.07± 4.33
respectively as compared to healthy control (11±3.42) U/L.
Conclusion: Serum 5’-nucleotidase levels showed elevations
in mean value of three fold in viral hepatitis, 2.5 folds elevation
in alcoholic liver disease and two fold in cirrhosis as compared
of healthy control subjects. |
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| ISSN: | 2249-782X 0973-709X |