Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

Tumor-associated macrophages (TAMs) frequently help to sustain tumor growth and mediate immune suppression in the tumor microenvironment (TME). Here, we identified a subset of iron-loaded, pro-inflammatory TAMs localized in hemorrhagic areas of the TME. The occurrence of iron-loaded TAMs (iTAMs) cor...

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Bibliographic Details
Main Authors: Milene Costa da Silva, Michael O. Breckwoldt, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Michael Meister, Thomas Muley, Arne Warth, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka, Martina U. Muckenthaler
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
tumor-associated macrophages
macrophage polarization
hemolytic red blood cells
heme
iron
non-small cell lung cancer
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01479/full

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