Zebrafish <i>Oxr1a</i> Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging

Zebrafish <i>Oxr1a</i> Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging

Oxidation resistance gene 1 (<i>OXR1</i>) is essential for protection against oxidative stress in mammals, but its functions in non-mammalian vertebrates, especially in fish, remain uncertain. Here, we created a homozygous <i>oxr1a</i>-knockout zebrafish via the CRISPR/Cas9 (...

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Bibliographic Details
Main Authors: Hao Xu, Yu Jiang, Sheng Li, Lang Xie, Yi-Xi Tao, Yun Li
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Genes
Subjects:
<i>Oxr1a</i>
antioxidant defenses
oxidative stress
aging
p53 signaling pathway
apoptosis
Online Access:https://www.mdpi.com/2073-4425/11/10/1118

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