The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy

The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma: An In Vitro Study on a Novel Combination Strategy

The epidermal growth factor receptor (EGFR) is a therapeutic target in head and neck squamous cell carcinoma (HNSCC). Resistance to EGFR-targeted therapies, such as cetuximab, poses a challenging problem. This study aims to characterize acquired cetuximab resistance mechanisms in HNSCC cell lines by...

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Bibliographic Details
Main Authors: Hannah Zaryouh, Ines De Pauw, Hasan Baysal, Patrick Pauwels, Marc Peeters, Jan Baptist Vermorken, Filip Lardon, An Wouters
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Oncology
Subjects:
PI3K/Akt pathway
cetuximab
EGFR
HNSCC
Akt inhibitor
resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.697967/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.697967/full

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