Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer...

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Main Authors: Yu Fu, Inhan Lee, Yong Sun Lee, Xiaoyong Bao
Format: Article
Language:English
Published: Korea Genome Organization 2015-12-01
Series:Genomics & Informatics
Subjects:
neoplasms
neurodegenerative diseases
RSV replication, tRNA, tRNA-derived RNA fragments
Online Access:http://genominfo.org/upload/pdf/gni-13-94.pdf
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spelling doaj-9c036ba16e5c4784b3a53c26e38320772020-11-24T23:56:15ZengKorea Genome OrganizationGenomics & Informatics1598-866X2234-07422015-12-011349410110.5808/GI.2015.13.4.94162Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human DiseasesYu Fu0Inhan Lee1Yong Sun Lee2Xiaoyong Bao3Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.miRcore, Ann Arbor, MI 48105, USA.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.http://genominfo.org/upload/pdf/gni-13-94.pdfneoplasmsneurodegenerative diseasesRSV replication, tRNA, tRNA-derived RNA fragments
collection DOAJ
language English
format Article
sources DOAJ
author Yu Fu
Inhan Lee
Yong Sun Lee
Xiaoyong Bao
spellingShingle Yu Fu
Inhan Lee
Yong Sun Lee
Xiaoyong Bao
Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
Genomics & Informatics
neoplasms
neurodegenerative diseases
RSV replication, tRNA, tRNA-derived RNA fragments
author_facet Yu Fu
Inhan Lee
Yong Sun Lee
Xiaoyong Bao
author_sort Yu Fu
title Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_short Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_full Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_fullStr Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_full_unstemmed Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_sort small non-coding transfer rna-derived rna fragments (trfs): their biogenesis, function and implication in human diseases
publisher Korea Genome Organization
series Genomics & Informatics
issn 1598-866X
2234-0742
publishDate 2015-12-01
description tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.
topic neoplasms
neurodegenerative diseases
RSV replication, tRNA, tRNA-derived RNA fragments
url http://genominfo.org/upload/pdf/gni-13-94.pdf
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AT inhanlee smallnoncodingtransferrnaderivedrnafragmentstrfstheirbiogenesisfunctionandimplicationinhumandiseases
AT yongsunlee smallnoncodingtransferrnaderivedrnafragmentstrfstheirbiogenesisfunctionandimplicationinhumandiseases
AT xiaoyongbao smallnoncodingtransferrnaderivedrnafragmentstrfstheirbiogenesisfunctionandimplicationinhumandiseases
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