Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli

LpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or t...

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Main Authors:	Thomas E. Bohl, Ke Shi, John K. Lee, Hideki Aihara
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02712-9

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spelling	doaj-9c01b2d7a03c4b53b30d257bedbede9c2021-05-11T09:31:49ZengNature Publishing GroupNature Communications2041-17232018-01-019111310.1038/s41467-017-02712-9Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coliThomas E. Bohl0Ke Shi1John K. Lee2Hideki Aihara3Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin CitiesDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin CitiesDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin CitiesDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota Twin CitiesLpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or the membrane.https://doi.org/10.1038/s41467-017-02712-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara
spellingShingle	Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli Nature Communications
author_facet	Thomas E. Bohl Ke Shi John K. Lee Hideki Aihara
author_sort	Thomas E. Bohl
title	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_short	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_full	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_fullStr	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_full_unstemmed	Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli
title_sort	crystal structure of lipid a disaccharide synthase lpxb from escherichia coli
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-01-01
description	LpxB is a membrane-associated glycosyltransferase required for bacterial lipopolysaccharide biosynthesis. Here, Bohl et al. solve the crystal structure of a soluble LpxB variant, showing an intertwined C-terminally swapped dimer, and residues likely mediating association with lipidic substrates or the membrane.
url	https://doi.org/10.1038/s41467-017-02712-9
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Crystal structure of lipid A disaccharide synthase LpxB from Escherichia coli

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