Identifying Drug Sensitivity Subnetworks with NETPHIX

Summary: Phenotypic heterogeneity in cancer is often caused by different patterns of genetic alterations. Understanding such phenotype-genotype relationships is fundamental for the advance of personalized medicine. We develop a computational method, named NETPHIX (NETwork-to-PHenotype association wi...

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Bibliographic Details
Main Authors: Yoo-Ah Kim, Rebecca Sarto Basso, Damian Wojtowicz, Amanda S. Liu, Dorit S. Hochbaum, Fabio Vandin, Teresa M. Przytycka
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220308117